Michael Lohan and his girlfriend, Kate Major, had another fight-- and this one ended with her in handcuffs for DUI.

Lohan claims they were in an argument at their Florida home when she hit him multiple times in the face.

Lohan called 911 and as cops arrived, Kate was fleeing in her car.

She crashed into some bushes near the house, though, and was busted for allegedly driving intoxicated.

She was reportedly still in custody and getting booked for DUI and possibly domestic battery.